The Cornell College of Agriculture and Life Sciences (CALS or Ag School) is a statutory college located on the Cornell University campus in Ithaca, New York. With enrollment of approximately 3,100 undergraduate and 1,000 graduate students, CALS is the third-largest college of its kind in the United States and the second-largest undergraduate college on the Cornell campus.

Established as a Land-grant college, CALS administrates New York's cooperative extension program jointly with the College of Human Ecology. CALS runs the New York State Agricultural Experiment Station in Geneva, New York, and the Cornell University Agricultural Experiment Station, as well as other research facilities in New York.

In 2007-08, CALS total budget (excluding the Geneva Station) is $283 million, with $96 million coming from tuition and $52 million coming from state appropriations. The Geneva Station budget was an additional $25 million.