The Sapienza University of Rome (Italian: Sapienza – Università di Roma), also called simply Sapienza or the University of Rome, is a research university that is located in Rome, Italy. Formally known as Università degli Studi di Roma "La Sapienza", it is one of the largest European universities by enrollments and one of the oldest in history, founded in 1303. The University is one of the most prestigious Italian universities and in the world, commonly ranking first in national rankings and in Southern Europe. In 2018, 2019 and 2021 it ranked first in the world for classics and ancient history.

Most of the Italian ruling class studied at Sapienza. Sapienza educated numerous notable alumni, including many Nobel laureates, Presidents of the European Parliament and European Commissioners, heads of several nations, notable religious figures, scientists and astronauts. In September 2018, it was included in the top 100 of the QS World University Rankings Graduate Employability Ranking.