The Duke–NUS Medical School (Duke–NUS) is a graduate medical school in Singapore. The school was set up in April 2005 as the Duke–NUS Graduate Medical School, Singapore's second medical school, after the Yong Loo Lin School of Medicine, and before the Lee Kong Chian School of Medicine. It is a collaboration between Duke University from the United States and the National University of Singapore from Singapore.

Duke-NUS follows a hybrid American–Singaporean model of post-baccalaureate medical education, in which students begin their medical studies after earning a bachelor’s degree. Students are awarded degrees from both Duke University School of Medicine and the National University of Singapore.