The James McKelvey School of Engineering is a part of Washington University in St. Louis. Founded in 1854, the engineering school is a research institution occupying seven buildings on Washington University's Danforth Campus. Research emphasis is placed on cross-disciplinary technologies in the areas of alternative energy, environmental engineering & sustainable technology, biotechnology, information technology, and nanotechnology/materials science.

On January 31, 2019, the School of Engineering & Applied Science was renamed the James McKelvey School of Engineering, in honor of trustee and distinguished alumnus Jim McKelvey Jr., the co-founder of Square, after his donation of an undisclosed sum that the school's dean, Aaron Bobick, said has been the largest in the school's 162-year history.

Washington University is currently undergoing a $360 million campus transformation project which includes the construction of two new McKelvey buildings: Henry A. and Elvira H. Jubel Hall, which houses the Department of Mechanical Engineering & Materials Science, and James M. McKelvey, Sr. Hall, which will be completed in 2020 and open in 2021 and will house the Department of Computer Science & Engineering