The Michael G. DeGroote School of Medicine, known as the McMaster University School of Medicine prior to 2004, is the medical school of McMaster University in Hamilton, Ontario, Canada. It is operated by the McMaster Faculty of Health Sciences. It is one of two medical programs in Canada, along with the University of Calgary, that operates on an accelerated 3-year MD program, instead of the traditional 4-year MD program.

Currently, McMaster ranks 11th in the world and 2nd in Canada for medicine according to the Times Higher Education World University Rankings 2021.[3] In 2012, McMaster ranked 14th in the world and 1st in Canada in medicine, according to the Times Higher Education Rankings.[4]

The school received 5,228 applications for the Class of 2022, the most applications of any medical school in Canada, and had an acceptance rate of 3.9%. The average cumulative GPA of entering undergraduates in the Class of 2020 was 3.87 and the average MCAT Verbal Reasoning or Critical Analysis and Reasoning Skills score was 129, a score in the 95th percentile. Unlike many other medical schools, McMaster University's medical school does not drop any courses or years in their GPA calculation, as well as only uses the MCAT Verbal score in the MCAT component of their admissions calculation. Students also have to write the CASPer admissions test, first developed by McMaster in 2010.

Since its formation in 1965, the school invented the small-group, case-based learning curriculum which is now known as PBL or problem-based learning. In addition, the school was the first in the world to institute a 3-year M.D. program in 1969, with classes being held year round. In the 1980s, McMaster developed and coined the term "evidence-based medicine" as a way to approach clinical problem solving. McMaster also developed the Multiple Mini Interview (MMI) system in 2001 for medical school admissions which has been adopted as part of the admissions system in professional schools around the world. In 2010, McMaster developed the CASPer test for medical school admissions, which has recently been adopted at several medical schools across North America.