The École polytechnique fédérale de Lausanne (EPFL) is a research institute and university in Lausanne, Switzerland, that specializes in natural sciences and engineering. It is one of the two Swiss Federal Institutes of Technology, and it has three main missions: education, research and technology transfer.

The QS World University Rankings ranks EPFL 14th in the world across all fields in their 2020/2021 ranking, whereas Times Higher Education World University Rankings ranks EPFL as the world's 19th best school for Engineering and Technology in 2020.

EPFL is located in the French-speaking part of Switzerland; the sister institution in the German-speaking part of Switzerland is the Swiss Federal Institute of Technology in Zurich (ETH Zurich). Associated with several specialized research institutes, the two universities form the Swiss Federal Institutes of Technology Domain (ETH Domain), which is directly dependent on the Federal Department of Economic Affairs, Education and Research. In connection with research and teaching activities, EPFL operates a nuclear reactor CROCUS, a Tokamak Fusion reactor, a Blue Gene/Q Supercomputer and P3 bio-hazard facilities