The main St Lucia campus occupies much of the riverside inner suburb of St Lucia, southwest of the Brisbane central business district. Other UQ campuses and facilities are located throughout Queensland, the largest of which are the Gatton campus and the Mayne Medical School. UQ's overseas establishments include UQ North America office in Washington D.C., and the UQ-Ochsner Clinical School in Louisiana, United States.

The university offers associate, bachelor, master, doctoral, and higher doctorate degrees through a college, a graduate school, and six faculties. UQ incorporates over one hundred research institutes and centres offering research programs, such as the Institute for Molecular Bioscience, Boeing Research and Technology Australia Centre, the Australian Institute for Bioengineering and Nanotechnology, and the UQ Dow Centre for Sustainable Engineering Innovation. Recent notable research of the university include pioneering the invention of the HPV vaccine that prevents cervical cancer, developing a COVID-19 vaccine that was in human trials, and the development of high-performance superconducting MRI magnets for portable scanning of human limbs.

UQ counts two Nobel laureates (Peter C. Doherty and John Harsanyi), over a hundred Olympians winning numerous gold medals, and 117 Rhodes Scholars among its alumni and former staff. UQ's alumni also include UCSF Chancellor Sam Hawgood, the first female Governor-General of Australia Dame Quentin Bryce, President of King's College London Ed Byrne, member of United Kingdom's Prime Minister Council for Science and Technology Max Lu, Oscar and Emmy awards winner Geoffrey Rush, triple Grammy Award winner Tim Munro, the former CEO and Chairman of Dow Chemical, and current Director of DowDuPont Andrew N. Liveris.