The Duke University School of Medicine, commonly known as Duke Med, is the medical school of Duke University. It is located in the Collegiate Gothic-style West Campus of Duke University in Durham, North Carolina. The School of Medicine, along with the Duke University School of Nursing, Duke University Hospital, Duke Regional Hospital, Duke Children's Hospital, Duke Raleigh Hospital, and other affiliated hospitals, clinics, and laboratories, make up the Duke University Health System. Established in 1925 by James B. Duke, the School of Medicine has earned its reputation as an integral part of one of the world's foremost patient care and biomedical research institutions.

Clinical rotations by medical students and residents occur within the Duke University Health System, a fully integrated academic health care system encompassing a tertiary-care hospital and specialty clinics on the Medical Center campus, two community hospitals, a VA hospital, home health and hospice services, a network of primary care physicians, and other affiliated partners across the SE United States. Duke University Hospital is consistently ranked among the top 20 of some 5,700 American hospitals by U.S. News & World Report. Furthermore, the School of Medicine is especially noted for its groundbreaking biomedical research, bringing in nearly $700 million in NIH-sponsored projects in 2016.